منابع مشابه
Exit from Mitosis Spindle Pole Power
of mitosis when the bud cell body receives a progeny spindle pole. The signal that this has occurred is generated when a GTP binding protein located on the outside of the spindle pole is brought into the vicinity of an activator confined to the bud. Thus, the outcome of a motile process, mitotic spindle-mediated segregation of replicated chromosomes, is monitored spatially. To the observer, one...
متن کاملTesting cyclin specificity in the exit from mitosis.
Cyclical inactivation of B-type cyclins has been proposed to be required for alternating DNA replication and mitosis. Destruction box-dependent Clb5p degradation is strongly increased in mitotic cells, and constitutive overexpression of Clb5p lacking the destruction box resulted in rapid accumulation of inviable cells, frequently multiply budded, with DNA contents ranging from unreplicated to a...
متن کاملSpatial signals link exit from mitosis to spindle position
In budding yeast, if the spindle becomes mispositioned, cells prevent exit from mitosis by inhibiting the mitotic exit network (MEN). The MEN is a signaling cascade that localizes to spindle pole bodies (SPBs) and activates the phosphatase Cdc14. There are two competing models that explain MEN regulation by spindle position. In the 'zone model', exit from mitosis occurs when a MEN-bearing SPB e...
متن کاملLTE1 promotes exit from mitosis by multiple mechanisms
In budding yeast, alignment of the anaphase spindle along the mother-bud axis is crucial for maintaining genome integrity. If the anaphase spindle becomes misaligned in the mother cell compartment, cells arrest in anaphase because the mitotic exit network (MEN), an essential Ras-like GTPase signaling cascade, is inhibited by the spindle position checkpoint (SPoC). Distinct localization patterns...
متن کاملPropagation of centromeric chromatin requires exit from mitosis
Centromeres direct chromosomal inheritance by nucleating assembly of the kinetochore, a large multiprotein complex required for microtubule attachment during mitosis. Centromere identity in humans is epigenetically determined, with no DNA sequence either necessary or sufficient. A prime candidate for the epigenetic mark is assembly into centromeric chromatin of centromere protein A (CENP-A), a ...
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ژورنال
عنوان ژورنال: Cell
سال: 2000
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)00031-3